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in those journals were presented in a manner consistent with journal policies. However, 28.5 of articles (50.3 average) left the sex of animal subjects unspecified, suggesting that journal policies are often not followed. Unreported sexes of test subject animals may cause problems for reproducibility of research and interpretations of results. The artist himself insists the 12-metre-high sculpture is not sexually explicit and says his work is to highlight the domestication of animals by humans for agriculture and industry. Role of MYC-regulated long noncoding RNAs in cell cycle regulation and tumorigenesis. We classified each article by whether or not it reported test subject sex, and by which sex was included. We treated each experiment as a separate analysis; in other words, for n number of separate experiments, each experiment was counted as 1/n studies.

Wang SH, Yeh SH, Shiau CW, Chen KF, Lin WH, Tsai TF,. This trend was reflected in all five of the gefickt oncology journals, with each publishing similar percentages of studies that used males, females, or both sexes ( Figure 3 ). The percentages of studies including both sexes ranged from.1.4 depending on the journal. Flórez-Vargas O, Brass A, Karystianis G, Bramhall M, Stevens R, Cruickshank S,. Cancer Cell 2015; 27: 10922. Different immune cells mediate mechanical pain hypersensitivity in male and female mice. Sorge RE, Mapplebeck JC, Rosen S, Beggs S, Taves S, Alexander JK,.

Weird, animals, Sex, and Genome Evolution.Annual Review of Animal.

Weird, animals, Sex, and Genome Evolution Annual Review

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Such differences in basic properties are also reflected in oncology.

Such sexual dimorphism in pain mechanisms indicates that male and female mice are not interchangeable in pain studies. Males and females can have different biological properties even on the most basic cellular levels 4,. All five of the journals included in this study had policies recommending that the sexes of animal test subjects be delineated in the article. Neurosci Biobehav Rev 2011; 35: 56572. Thus, this publication included the equivalent.25 female subject studies,.5 male subject studies, and.25 unspecified studies. This represents a widespread problem in oncological preclinical research, for these low levels of sex-reporting rates undoubtedly hinder the reproducibility of research and cloud accurate interpretations of results, especially since increasing evidence indicates that there are clinically significant differences between male and female physiologies. However, even after we excluded studies with justifications, the same trend persisted.

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